Prime Organics makes chemicals! Be it a single step or multi-step reactions, milligrams to multi-kilograms, our motto is "Sure, we can make that!"

Our scientists can provide process development and optimization for compounds heading into production. We have a successful record of transferring processes developed in our labs to large scale manufacturing as well as cGMP.

Some of the manufacturing services we offer:

• Milligram to multi-kilogram synthesis
• Multi-step synthesis (current record: 22 steps)
• Process R&D
• Combinatorial Chemistry
• Building Blocks
• Libraries
• Medicinal Intermediates
• Impurity Synthesis
• Heterocycles
• Nucleosides/RNA
• Monomers/Polymers
• Rare Amino Acids
• Taxanes
• Acrylamides, pyridinium ylides and other monomers for HPLC supports
• Fmoc and Boc amino acids and peptide coupling reagents
• Fluorescent and biotinylated linkers and phosphoramidites for oligonucleotide synthesis
• Intermediates for antisense oligonucleotides
• 13C- and 15N-enriched protected amino acids and nucleosides
• Activated affinity supports
• Heavy-metal chelators for water purification
• Hydrogenation and other high-pressure chemistry

Prime Organics' FTE program (Full Time Equivalent) is ideal for process development, method validation, exploratory work, and fundamental research. The service may be provided for periods ranging from weeks to years.


Reaction Capabilities:

Prime Organics has the capability of performing these reactions in mg to multi-kg scale.

Acidic Reactions, Acetylation, Acid Chlorination, Acylation, Alcoholysis, Alcoxylation, Alkylation, Amidation, Amination, Aminolysis , Ammoxidation, Bromination, Carbomethylation, Carboxylation, Carboxymethylation, Chloridation, Chlorination, Chloromethylation, Chlorosulfonation, Condensation, Cyclization, Cyanation, Dealkylation, Decarboxylation, Dehydrogenation, Dehydrohalogenation, Diazotization, Enantiomeric Resolution, Epoxidation, Esterification, Ethylenation (high pressure), Ethoxylation, Fischer Reaction, Formylation, Frationated Distillation, Friedel Crafts Reaction, Grignard Reaction, High Pressure Reactions, High Vacuum Distillation, Hydride Reductions, Hydrogenation, Hydrolysis, Hydroxylation, Iodination, Isomerization, Knoevenagel Reaction, Liquid Ammonia Reactions, Maleation, Mannich Reaction, Methylation, Nitration Nitric Acid Oxidation, Nitrozation, Oxidation, Peptide Coupling, Phase Transfer Reaction, Quaternization, Reduction, Reductive Alkylation, Reductive Amination, Reformatsky, Sandmeyer Reaction, Saponification, Sodamide Reactions, Sulfonation, Tosylations, Transesterification, Ultra/nanofiltration, Vilsmeier reaction, Vinylation.

Prime Organics has a laboratory dedicated to combinatorial chemistry that can produce and evaluate potential library schemes and groups of building blocks.